T cell expression of CIITA represses Th1 immunity

T cell expression of CIITA represses Th1 immunity.

Despite the fact that major histocompatibility complex class II transactivator (CIITA) has been known to be involved in Th1/Th2 balance in addition to its major role as a master regulator for the expression of MHC class II genes, the exact role of CIITA in Th1/Th2 balance is still controversial. To investigate whether the Th1/Th2 balance could be modulated by T cell specific expression of CIITA...

Programming by CIITA Deficiency Altered Th1 Cell Differentiation

CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity.

The activation, proliferation, differentiation, and trafficking of CD4 T cells is central to the development of type I immune responses. MHC class II (MHCII)-bearing dendritic cells (DCs) initiate CD4(+) T cell priming, but the relative contributions of other MHCII(+) APCs to the complete Th1 immune response is less clear. To address this question, we examined Th1 immunity in a mouse model in w...

Analysis of T - Cell Immunity

1. Abstract 2. Introduction 3. Validating assays for use as surrogate to protective or therapeutic immunity 4. Laboratory issues in improving accuracy and precision 5. Common immunologic monitoring techniques 5.1. T cell proliferation 5.2. Cytolytic T cell assay 5.3. Enzyme linked immunosorbent spot (ELIspot) assay 5.4. Cytokine flow cytometry 5.5. Tetramers 6. Emerging techniques and concepts ...

Altered expression of cell cycle regulators in adult T-cell leukemia/lymphoma patients

Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1).  HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and comp...